Parkinson’s for patients with PD and have

Parkinson’s disease
(PD) is the common neurodegenerative disorder which can significantly impair
the quality of people either sex aged 60years and above worldwide. It leads to
motor, emotional and behavioural dysfunction. Impairment of dopamonergic neurotransmission
in PD due to progressive loss of dopaminergic neurons is documented
pathologically.1The available pharmacological interventions provide
only limited symptomatic relief  for
patients with PD and have little efficacy in reversing neuropathological
changes.

       Supplement of dopamine remains the
primary therapy to improve the functional capacity and quality of life in PD.
But motor disorders like dyskinesia,rigidity and tremors result from chronic
neuroleptic treatment. The neuroleptic induced neurological disorders may not
be improved by the supplement of dopamine due to chronic blockade of dopamine D2
receptors by the neuroleptic drugs like phenothiazine compounds. The
dopamine supersensitivity  hypothesis
proposes that antipsychotic  drug treatment
causes hypersensitization of dopamine D2 receptors. This disturbs
the dopamine levels in the brain, responsible for the motor symptoms resulting
in motor dysfunction.2 Morpurgo in 1962 described a direct method to
screen the drugs affecting dopamine receptors. Catatonia is a state of
neurogenic motor immobility and behavioural abnormality manifestations with
stupor.3  The
occurrence and irreversibility of this neurological disorder with motor
immobility in drug induced parkinsonism has been considered as a major clinical
issue in the treatment of schizophrenic patients.4

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       Bioactive derivatives of plants such as
flavonoids, stilbenoids and alkaloids possess potent anti-oxidative and
anti-inflammatory properties that improve the mitochondrial function and serve
as cognitive enhancers.5 Considering the
importance of searching for new compounds without any side effects with
potential usefulness in the prevention of drug induced parkinsonism, the
protective effect of Curcumin longa
in haloperidol induced catatonia and related behavioral alterations will be
examined in this study. The aqueous extract of Curcumin longa being a herbal product  has a tendency of passing through blood brain
barrier (BBB) and also has antioxidant activity, which may prove effective in
treating PD and related neurological disorders.