Damage to the peripheral nervous system can result in this disease. Peripheral Neuropathy develops when the peripheral nerves of the body parts becomes damaged. For instance, in the hands, arms and feet, causing weakness, numbness and pain. Communication between neurons in the CNS become compromised.The peripheral nerves send information from your brain and spinal cord (CNS) to the rest of your body. They also carry signals from CNS to the muscles in order to generate movement. Damage to the PNS interferes with these vital networks by distorting or interrupting the signals being transmitted. Damaging these nerve disrupts them functioning normally. They can send signals of pain when there’s nothing causing pain, or may not send a pain signal at all when something is harming you. This can be because of an injury, illness/ infection, genetic disorders.Guillain-Barre syndrome is an example of an acute neuropathy, the immune system attacks part of the PNS and impairs transmitting and receiving signals, the symptoms can appear suddenly, with a rapid deterioration rate of nerves are fatal. Though it can be chronic and some people may experience slow progress of the disease. The nerve damage is often as a result of diabetes (high blood sugar levels) because the nerve fibres become damaged, because there is a complex interaction between the blood vessels and the nerves. The body can’t naturally repair damaged nerve tissues, which means that they are likely to weaken at a quicker rate. Though, the exact reason as to why people develop this is unknown, the link between the levels of blood-sugar and nerve transmission can be seen. There may be reason to suggest that the levels of other factors i.e. pH, alcohol, nutrients etc. could also have an effect on how efficient nerve function is.How transmission is supposed to occur normally:How it affects the body:Motor nerve damage is associated with muscle weakness. Fasciculations may occur as uncontrolled muscle twitching which can be seen under the skin, muscle atrophy and decreased reflexes.Sensory nerve damage; Larger sensory fibres within the myelin sheath, are associated with vibration and touch. These can be impaired, resulting in a general decrease in sensation. The sensation is mainly lost in hands and feet. As a result of the nerve damage there is loss of reflexes. Loss of position sense means individuals are unable to coordinate complicated movements like walking or clasping hooks.Smaller sensory fibres do not contain myelin sheaths. These fibres transmit sensations of pain and if these fibres are damaged, the ability to feel pain or a change in temperature is reduced. People may fail to sense that they have been injured from a cut which is becoming infected. Others may not detect pain that warns of a heart attack.Neuropathic pain is a common, affecting the emotional well-being and overall quality of life of those who are affected. Over a long period of time, sensory neuropathy may lead to changes in the skin, hair, and can even damage the joints and bones.Autonomic nerve damage affects the parasympathetic and sympathetic nerves of the PNS. It leads to an inability to control muscles that expand or contract blood vessels in order to regulate blood pressure. Symptoms can include dizziness or fainting. Irregular heartbeats may also occur.Peripheral neuropathy can also affect the nerves controlling the involuntary functions of the heart and cardiovascular system (cardiovascular autonomic neuropathy). Treatment may be required in order to increase blood pressure or even a pacemaker so that the heart can contract/beat faster or slower when needed. This can also affect the pressure on the heart and how quickly the heart can supply oxygen to the organs that need it.