About 18 million people in the United States have an
alcohol use disorder, according to National Institutes of Health statistics.
The vast majority go untreated. An
estimated 88,000 people (approximately 62,000 men and 26,000 women) die
from alcohol-related causes annually, making alcohol the third leading
preventable cause of death in the United States. The first is tobacco, and the
second is poor diet and physical inactivity. In 2014, alcohol-impaired driving
fatalities accounted for 9,967 deaths (31 percent of overall driving
Our society is not efficiently equipped with pharmacological
treatments to treat people who want to stop substance addiction, because this
is an extremely difficult human genetics problem. We need a comprehensive
understanding of the molecular effects of alcohol and drugs to come up a better
rational treatments. We should also be able to warn people who are more
susceptible to developing a dependence in future.
addiction takes a massive toll on the society globally. Novel animal models are
needed to test new treatments and understand the basic mechanisms underlying
addiction. Recent studies indicate that addiction has been prevalent since
ancient times and many mechanisms that underlie human addiction are also
present in invertebrates. Emerging evidence suggests that C. elegans is an excellent model to identify molecular mechanisms
that mediate drug-induced behavior and potential targets for medications
development for various addictive compounds. C. elegans has been used to model many types of disorders in
humans, including neurologic and psychiatric disorders ranging from Parkinson’s
disease to Autism. Accumulating evidence indicates that C.
elegans is an
excellent model to identify molecular mechanisms that mediate drug effects and
potential targets for medications development for various addictive compounds.
I want to
find if we can come up a solution to substance abuse rehabilitation using
transient receptor potential channels and insulin signaling in C. elegans.
is significant scientific breakthroughs currently on molecular determinants of
drug addiction but there are major limitations that exist on the effective
treatment strategies for many forms of drug addiction. Thus, there is a real
need to translate the available research regarding molecular mechanisms of drug
addictions derived from neuro-biological research into the discovery of new